Telomere shortening in mucosa surrounding the tumor: Biosensor of field cancerization and prognostic marker of mucosal failure in head and neck squamous cell carcinoma. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Boscolo-Rizzo, Paolo; Rampazzo, Enrica; Perissinotto, Egle; Piano, Maria Assunta; Giunco, Silvia; Baboci, Lorena; Spinato, Giacomo; Spinato, Roberto; Tirelli, Giancarlo; Da Mosto, Maria Cristina; Del Mistro, Annarosa; De Rossi, Anita
• Is Part Of: Oral oncology. Volume 51:Issue 5(2015:May)
• Page Start: 500
• Page End: 507
• Publication Date: 2015-05
• Subjects: Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2015.02.100
• Languages: English
• ISSNs: 1368-8375

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title id="st100">Highlights</title> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0155">Evaluation of telomere length and levels of TERT in cancer tissues and tumor surrounding mucosa (SM).</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0160">No correlation was found between age and telomere length in SM.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0165">Patients with short telomeres in SM had a significantly higher risk of mucosal failure.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0170">Patients with high TERT levels in cancer tissues had a significantly higher risk of regional failure.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0175">Telomere erosion is a biosensor of field cancerization and precedes the reactivation of TERT in SM.</p> </list-item> </list> </p> </sec> </abstract>