PDK1 is a potential therapeutic target against angiosarcoma cells. Issue 1 (April 2015)

• Record Type: Journal Article
• Authors: Wada, Makoto; Horinaka, Mano; Yasuda, Shusuke; Masuzawa, Mikio; Sakai, Toshiyuki; Katoh, Norito
• Is Part Of: Journal of dermatological science. Volume 78:Issue 1(2015:Apr.)
• Page Start: 44
• Page End: 50
• Publication Date: 2015-04
• Subjects: Dermatology -- Periodicals; Skin Diseases -- Periodicals; Dermatologie -- Périodiques; 616.5005
• DOI: 10.1016/j.jdermsci.2015.01.015
• Languages: English
• ISSNs: 0923-1811

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The PI3K inhibitor and mTOR inhibitor induced G1 cell cycle arrest.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Cyclin D levels were decreased by knockdown of PDK1, not by AKT inhibitor.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">The knockdown of PDK1 inhibited colony formation than the mTOR inhibitor.</p> </list-item> </list> </p> </sec> </abstract>