Identification of HSP70-inducing activity in Arnica montana extract and purification and characterization of HSP70-inducers. Issue 1 (April 2015) - Usui, Keiko
Highlights We here searched for HSP70-inducers from a library of herbal extracts that have already been approved as quasi-pharmaceutical products in Japan. We selected an ethanol extract of Arnica montana and purified an HSP70-inducer, AM-2 (helenalin 2-methylbutyrate). Pre-treatment of cells with AM-2 or Arnica montana extract decreased melanin production. These results suggest that AM-2 and Arnica montana extract could be beneficial for use in hypopigmenting cosmetics as a consequence of their stimulatory effects on HSP70 expression.