Association of TNF-α-308(GG), IL-10−819(TT), IL-10−1082(GG) and IL-1R1+1970(CC) genotypes with the susceptibility and progression of leprosy in North Indian population. Issue 1 (May 2015)

• Record Type: Journal Article
• Authors: Tarique, Mohd; Naqvi, Raza Ali; Santosh, K.V.; Kamal, Vineet Kumar; Khanna, Neena; Rao, D.N.
• Is Part Of: Cytokine. Volume 73:Issue 1(2015)
• Page Start: 61
• Page End: 65
• Publication Date: 2015-05
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.01.014
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st065">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0090">SNPs at promoter directly affect the cytokine production.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0095">Leprosy progression is associated with high producer genotypes of IL-10 and TNFα.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0100">IL-10⁻¹⁰⁸² GG masks the production of high producer genotype of TNFα in leprosy.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0105">TNFα⁻³⁰⁸GG, IL-10⁻⁸¹⁹TT is predominant genotypes in our studied patients.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0110">Individuals with these genotypes and IL-10⁻¹⁰⁸² GG are susceptible to leprosy.</p> </list-item> </list> </p> </sec> </abstract>