Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblasts. Issue 1 (May 2015)

• Record Type: Journal Article
• Authors: Cavalla, Franco; Osorio, Constanza; Paredes, Rodolfo; Valenzuela, María Antonieta; García-Sesnich, Jocelyn; Sorsa, Timo; Tervahartiala, Taina; Hernández, Marcela
• Is Part Of: Cytokine. Volume 73:Issue 1(2015)
• Page Start: 114
• Page End: 121
• Publication Date: 2015-05
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.02.001
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st085">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0185">We stimulated hPDLF with H₂O₂ in the presence/absence of Ilomastat (MMPs inhibitor).</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0190">Oxidant conditions increased anti-oxidant enzymes, cytokines and MMPs.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0195">Oxidant conditions favored cell migration in a MMP-dependent fashion.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0200">Ilomastat modified the effects of H₂O₂ over cytokine levels and reduced cell migration.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0205">There is a bidirectional regulation system between MMPs and cytokines.</p> </list-item> </list> </p> </sec> </abstract>