Genetic conjugation of components in two pneumococcal fusion protein vaccines enhances paediatric mucosal immune responses. Issue 14 (30th March 2015)

• Record Type: Journal Article
• Authors: Pope, Caroline; Oliver, Elizabeth H.; Ma, Jiangtao; Langton Hewer, Claire; Mitchell, Tim J.; Finn, Adam
• Is Part Of: Vaccine. Volume 33:Issue 14(2015)
• Page Start: 1711
• Page End: 1718
• Publication Date: 2015-03-30
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.02.012
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">A new, affordable pneumococcal vaccine offering broader protection is needed.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Fusion of PsaA to Δ6Ply enhances CD4+ T-cell responses in children's nasopharynges.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">CD4+ T-cell responses had a Th1/Th17 cytokine profile.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Membrane binding activity of Ply/Δ6Ply may confer valuable adjuvant properties.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Non-toxic pneumolysoids may be suitable for inclusion in future vaccines.</p> </list-item> </list> </p> </sec> </abstract>