Kindlin-2 induced by TGF-β signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9. Issue 1 (28th May 2015)

• Record Type: Journal Article
• Authors: Zhan, Jun; Song, Jiagui; Wang, Peng; Chi, Xiaochun; Wang, Yunling; Guo, Yongqing; Fang, Weigang; Zhang, Hongquan
• Is Part Of: Cancer letters. Volume 361:Issue 1(2015)
• Page Start: 75
• Page End: 85
• Publication Date: 2015-05-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.02.039
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Kindlin-2 is upregulated but HOXB9 is downregulated by TGF-β1 in PDAC cells.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Kindlin-2 upregulates but HOXB9 downregulates TβRI in PDAC cells.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Kindlin-2 and TGFβ signaling constitute a positive feedback loop that regulates PDAC progression.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Enhanced expression of Kindlin-2 predicts a poor prognosis for PDAC patients.</p> </list-item> </list> </p> </sec> </abstract>