The twisted relation between Pnu and SWEET transporters. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Jaehme, Michael; Guskov, Albert; Slotboom, Dirk Jan
• Is Part Of: Trends in biochemical sciences. Volume 40:Issue 4(2015)
• Page Start: 183
• Page End: 188
• Publication Date: 2015-04
• Subjects: Biochemistry -- Periodicals; 572
• DOI: 10.1016/j.tibs.2015.02.002
• Languages: English
• ISSNs: 0968-0004

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">SWEET and Pnu transporters have similar structures but lack sequence similarity.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">A topological difference also raises questions about their evolutionary relatedness.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">A 3D domain swap can explain the topological differences.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">We propose a pathway by which the SWEET and Pnu transporters may have diverged.</p> </list-item> </list> </p> </sec> </abstract>