Site-specific characterization of envelope protein N-glycosylation on Sanofi Pasteur's tetravalent CYD dengue vaccine. Issue 11 (10th March 2015)

• Record Type: Journal Article
• Authors: Dubayle, Jean; Vialle, Sandrine; Schneider, Diane; Pontvianne, Jérémy; Mantel, Nathalie; Adam, Olivier; Guy, Bruno; Talaga, Philippe
• Is Part Of: Vaccine. Volume 33:Issue 11(2015)
• Page Start: 1360
• Page End: 1368
• Publication Date: 2015-03-10
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.01.047
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">First report assessing the site-specific N-glycosylation of the E-protein from CYD.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Both Asn67 and Asn153 sites are glycosylated.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">The most abundant glycoforms at each site of the E-protein are different.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">The main glycoform detected at Asn67 is able to interact with DC-SIGN co-receptor.</p> </list-item> </list> </p> </sec> </abstract>