Vaccination with recombinant L7/L12-truncated Omp31 protein induces protection against Brucella infection in BALB/c mice. Issue 2 (June 2015)

• Record Type: Journal Article
• Authors: Golshani, Maryam; Rafati, Sima; Dashti, Amir; Gholami, Elham; Siadat, Seyed Davar; Oloomi, Mana; Jafari, Anis; Bouzari, Saeid
• Is Part Of: Molecular immunology. Volume 65:Issue 2(2015:Jun.)
• Page Start: 287
• Page End: 292
• Publication Date: 2015-06
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.01.009
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We evaluate the immunogenicity and protective efficiency of the rL7/L12-TOmp31 against <italic>Brucella</italic>.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">rL7/L12-TOmp31 immunizations induce a vigorous humoral response.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">rL7/L12-TOmp31 immunization induces a Th1 cellular response.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">rL7/L12-TOmp31 immunization induces protection against <italic>B. melitensis</italic> and <italic>B. abortus</italic> challenge.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">rL7/L12-TOmp31 could be a potential antigen candidate for development of new subunit vaccines against <italic>B. melitensis</italic> and <italic>B. abortus</italic>.</p> </list-item> </list> </p> </sec> </abstract>