Subcellular localization and activation of ADAM proteases in the context of FasL shedding in T lymphocytes. Issue 2 (June 2015)

• Record Type: Journal Article
• Authors: Ebsen, Henriette; Lettau, Marcus; Kabelitz, Dieter; Janssen, Ottmar
• Is Part Of: Molecular immunology. Volume 65:Issue 2(2015:Jun.)
• Page Start: 416
• Page End: 428
• Publication Date: 2015-06
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.02.008
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0060"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">TCR/CD3/CD28-stimulation results in the release of soluble FasL from human T cells.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">FasL shedding by ADAM10 and ADAM17 is prevented by inhibition of Src kinases.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Both proteases and FasL are detectable in intracellular lysosomal compartments.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Without stimulation, ADAM10 and ADAM17 are not found in lipid raft platforms.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">An activation-induced raft positioning of the proteases results in FasL shedding.</p> </list-item> </list> </p> </sec> </abstract>