T lymphocyte-derived TNF and IFN-γ repress HFE expression in cancer cells. Issue 2 (June 2015)

• Record Type: Journal Article
• Authors: Reuben, Alexandre; Godin-Ethier, Jessica; Santos, Manuela M.; Lapointe, Réjean
• Is Part Of: Molecular immunology. Volume 65:Issue 2(2015:Jun.)
• Page Start: 259
• Page End: 266
• Publication Date: 2015-06
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.01.029
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0030"> <label></label> <p id="par0170">The hemochromatosis protein HFE has been showed to inhibit antigen-specific CD8⁺ T cell activation.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Tumor cells can express high levels of endogenous HFE.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Exposure of tumor cells to activated T cells results in tumor-HFE down-regulation.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">HFE inhibition is mediated through TNF and IFN-γ secretion.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">This modulation of HFE expression in tumor cells could affect recognition and clearance by the immune system.</p> </list-item> </list> </p> </sec> </abstract>