Plasma triglyceride determination can identify increased risk of statin-induced type 2 diabetes: A hypothesis. Issue 2 (April 2015)

• Record Type: Journal Article
• Authors: Armato, J; Ruby, R; Reaven, G
• Is Part Of: Atherosclerosis. Volume 239:Issue 2(2015)
• Page Start: 401
• Page End: 404
• Publication Date: 2015-04
• Subjects: Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2015.02.010
• Languages: English
• ISSNs: 0021-9150

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Objective</title> <p id="abspara0010">To evaluate the ability of plasma triglyceride (TG) measurements to identify statin-treated persons at accentuated risk of statin-induced type 2 diabetes (T2DM).</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">The experimental population consisted of nondiabetic, statin-treated patients (n = 469), classified as being at high risk for T2DM, subdivided on the basis of a plasma TG concentration of 1.7 mmol/L. Comparisons were made of demographic characteristics, concentrations of fasting glucose, insulin, HbA1<sub>c</sub>, and hs-CRP, oral glucose tolerance tests, estimates of insulin action and secretion, and lipid/lipoprotein profiles.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">Despite similar fasting glucose and HbA1<sub>c</sub> concentrations, patients with elevated TG concentrations displayed markers of increased risk of T2DM (insulin resistance and compensatory hyperinsulinemia), more adverse lipid/lipoprotein profiles, and increased prevalence of abnormal hs-CRP values.</p> </sec> <sec> <title id="sectitle0030">Conclusion</title> <p id="abspara0025">These findings demonstrate that plasma TG concentrations ≥ 1.7 mmol/L identified a subset of individuals at enhanced risk of developing statin-induced diabetes within a population classified prior to statin treatment as being at high risk of T2DM.</p> </sec> </abstract>