Prospective association of TV viewing with acute phase reactants and coagulation markers: English Longitudinal Study of Ageing. Issue 2 (April 2015)

• Record Type: Journal Article
• Authors: Hamer, Mark; Smith, Lee; Stamatakis, Emmanuel
• Is Part Of: Atherosclerosis. Volume 239:Issue 2(2015)
• Page Start: 322
• Page End: 327
• Publication Date: 2015-04
• Subjects: Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2015.02.009
• Languages: English
• ISSNs: 0021-9150

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Objective</title> <p id="abspara0010">Inflammatory processes are putative mechanisms underlying the detrimental health effects of sedentary behaviour but no long-term prospective data are available. We examined the longitudinal association between TV viewing, physical activity and inflammatory markers over a 4-year follow-up period.</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">Participants were 3612 men and women (mean age 64.1 ± 8.2 years) from the English Longitudinal Study of Ageing. Self-reported daily TV viewing was measured at baseline and 2 years follow up. Inflammatory markers (serum high-sensitivity C-reactive protein [CRP], white blood cell count [WBC], and fibrinogen) were measured at baseline (2008/09) and 4 years follow-up (2012/13).</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">On average, participants viewed TV for 5.1 ± 4.0 h/d, and there was an increase of 1.9 h/wk TV viewing over 2 years. In linear models adjusted for covariates including physical activity, TV viewing was not associated with log<sub>e</sub>CRP at follow-up (B = 0.004, 95% CI, −0.001, 0.009, p = 0.09) but was associated with WBC (B = 0.018, 95% CI, 0.005, 0.031, p = 0.006), and fibrinogen (B = 0.004, 95% CI, 0.00, 0.008, p = 0.035). In contrast, physical activity was inversely associated with CRP (p = 0.047) and WBC (p = 0.026), but not fibrinogen (p = 0.22). An increase in TV viewing (of at least 1 h/d) was associated with higher concentrations of CRP (p = 0.015) and WBC (p = 0.05) at follow up after adjustment for covariates and baseline TV viewing.</p> </sec> <sec> <title id="sectitle0030">Conclusions</title> <p id="abspara0025">Physical activity and sedentary behaviour have contrasting associations with markers of low grade inflammation over 4 years of follow-up. These behaviours may be important in influencing the pro-inflammatory state seen with ageing.</p> </sec> </abstract>