Establishment of a novel system for the culture and expansion of hepatic stem-like cancer cells. Issue 2 (1st May 2015)

• Record Type: Journal Article
• Authors: Li, Jiang; Yu, Yong; Wang, Jinghan; Yan, Zi; Liu, Hui; Wang, Ying; Ding, Min; Cui, Lei; Wu, Mengchao; Jiang, Xiaoqing; Qian, Qijun
• Is Part Of: Cancer letters. Volume 360:Issue 2(2015)
• Page Start: 177
• Page End: 186
• Publication Date: 2015-05-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.02.006
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">We established a medium that allows the culture and enrichment of HSC-like cells.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">These hepatic stem-like cancer cells exhibited typical stem cell properties.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">These cells showed stem cell markers, gain of EMT properties and drug resistance.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">These cells exhibited typical stronger tumor-initiating capabilities.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">The medium established an <italic>in vitro</italic> model for hepatic cancer stem cell (HCSC) studies.</p> </list-item> </list> </p> </sec> </abstract>