Fibronectin promotes cell proliferation and invasion through mTOR signaling pathway activation in gallbladder cancer. Issue 2 (1st May 2015)

• Record Type: Journal Article
• Authors: Cao, Yang; Liu, Xiyong; Lu, Wei; Chen, Yuanyuan; Wu, Xiangsong; Li, Maolan; Wang, Xu-an; Zhang, Fei; Jiang, Lin; Zhang, Yijian; Hu, Yunping; Xiang, Shanshan; Shu, Yijun; Bao, Runfa; Li, Huaifeng; Wu, Wenguang; Weng, Hao; Yen, Yun; Liu, Yingbin
• Is Part Of: Cancer letters. Volume 360:Issue 2(2015)
• Page Start: 141
• Page End: 150
• Publication Date: 2015-05-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.01.041
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0015"> <label></label> <p id="p0015">FN is overexpressed in GBC tissues and is associated with a worse prognosis in GBC patients.</p> </list-item> <list-item id="u1020"> <label></label> <p id="p1020">Exogenous FN treatment promotes the proliferation and invasiveness of GBC cells.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">The Akt/mTOR/4E-BP1 signaling pathway is critically involved in FN-induced GBC cell proliferation and invasion.</p> </list-item> </list> </p> </sec> </abstract>