Evaluation of Mycobacterium bovis double knockout mce2-phoP as candidate vaccine against bovine tuberculosis. Issue 2 (March 2015)

• Record Type: Journal Article
• Authors: García, Elizabeth; Bianco, María V.; Gravisaco, María José; Rocha, Rosana V.; Blanco, Federico C.; Bigi, Fabiana
• Is Part Of: Tuberculosis. Volume 95:Issue 2(2015)
• Page Start: 186
• Page End: 189
• Publication Date: 2015-03
• Subjects: 616.995
• DOI: 10.1016/j.tube.2015.01.001
• Languages: English
• ISSNs: 1472-9792

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Summary</title> <sec> <p id="abspara0010">In this study, a <italic>Mycobacterium bovis</italic> knockout strain in <italic>phoP-phoR</italic> and <italic>mce2</italic> operons was tested as an antituberculosis experimental vaccine in animal models. The double mutant strain was significantly more attenuated than the wild type strain in inmunocompetent and inmunodeficient mice. Vaccination with the double mutant protected mice against challenge with a virulent <italic>M. bovis</italic> strain.</p> </sec> </abstract>