Cortical hyperexcitability precedes lower motor neuron dysfunction in ALS. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Menon, Parvathi; Kiernan, Matthew C.; Vucic, Steve
• Is Part Of: Clinical neurophysiology. Volume 126:Issue 4(2015:Apr.)
• Page Start: 803
• Page End: 809
• Publication Date: 2015-04
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2014.04.023
• Languages: English
• ISSNs: 1388-2457

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st075">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0185">Cortical hyperexcitability appears to develop prior to onset of lower motor neuron dysfunction in amyotrophic lateral sclerosis (ALS).</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0190">Cortical hyperexcitability is intrinsic to ALS.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0195">Cortical hyperexcitability may be the primary event in ALS, suggesting a cortical origin of the disease.</p> </list-item> </list> </p> </sec> </abstract>