Diffuse sclerosing variant of papillary thyroid carcinoma—an update of its clinicopathological features and molecular biology. Issue 1 (April 2015)

• Record Type: Journal Article
• Authors: Pillai, Suja; Gopalan, Vinod; Smith, Robert A.; Lam, Alfred K.-Y.
• Is Part Of: Critical reviews in oncology/hematology. Volume 94:Issue 1(2015)
• Page Start: 64
• Page End: 73
• Publication Date: 2015-04
• Subjects: Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2014.12.001
• Languages: English
• ISSNs: 1040-8428

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The prevalence of DSVPTC varies from 0.7–6.6% of all papillary thyroid carcinoma.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Higher prevalence of DSVPTC was noted in paediatric patients and in patients affected by irradiation.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">DSVPTC tends to occur more frequently in women and in patients in third decade of life.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Macroscopically, DSVPTC can involve the thyroid gland extensively without forming a dominant mass.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Microscopic examination of DSVPTC revealed extensive fibrosis, squamous metaplasia and numerous psammoma bodies.</p> </list-item> <list-item id="lsti0030"> <label></label> <p id="par0030">DSVPTC had a higher incidence of lymph node metastases at presentation. Distant metastases were noted in approximately 5% of the cases.</p> </list-item> <list-item id="lsti0035"> <label></label> <p id="par0035">On genetic analysis, the occurrence of <italic>BRAF</italic> and <italic>RAS</italic> mutations are uncommon events in DSVPTC and activations of <italic>RET/PTC</italic> rearrangements are common.</p> </list-item> </list> </p> </sec> </abstract>