VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFβR signaling-dependent manner. Issue 1 (28th April 2015)

• Record Type: Journal Article
• Authors: Pham, Kien; Luo, Defang; Siemann, Dietmar W.; Law, Brian K.; Reynolds, Brent A.; Hothi, Parvinder; Foltz, Gregory; Harrison, Jeffrey K.
• Is Part Of: Cancer letters. Volume 360:Issue 1(2015)
• Page Start: 60
• Page End: 67
• Publication Date: 2015-04-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.02.005
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">VEGFRs are heterogeneously expressed by glioblastoma stem-like cells.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">VEGFR inhibitors increase GBM CXCR4 and enhance functional responses to CXCL12.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Combination of VEGFR and CXCR4 inhibitors slows progression of GBM xenografts.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Upregulation of GBM CXCR4 by VEGFR inhibitors is TGFβR signaling dependent.</p> </list-item> </list> </p> </sec> </abstract>