Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin. Issue 1 (28th April 2015)

• Record Type: Journal Article
• Authors: Torricelli, C.; Daveri, E.; Salvadori, S.; Valacchi, G.; Ietta, F.; Muscettola, M.; Carlucci, F.; Maioli, E.
• Is Part Of: Cancer letters. Volume 360:Issue 1(2015)
• Page Start: 17
• Page End: 27
• Publication Date: 2015-04-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.01.040
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Rottlerin inhibits proliferation and causes autophagic death in apoptosis-resistant MCF-7 breast cancer cells.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Autophagy is induced by PKCδ-, PP2A, - ERK-, PI3K/AKT-, Bcl2/Beclin- and AMPK-independent mTORC1 inhibition.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Rottlerin inhibits mTORC1 but not mTORC2 activity.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Ex vivo pull-down assay demonstrated that Rottlerin directly binds mTOR.</p> </list-item> </list> </p> </sec> </abstract>