Reactivity of copper–α-synuclein peptide complexes relevant to Parkinson's disease1. Issue 7 (8th July 2015)

• Record Type: Journal Article
• Authors: Dell'Acqua, Simone; Pirota, Valentina; Anzani, Cecilia; Rocco, Michela M.; Nicolis, Stefania; Valensin, Daniela; Monzani, Enrico; Casella, Luigi
• Is Part Of: Metallomics. Volume 7:Issue 7(2015:Jul.)
• Page Start: 1091
• Page End: 1102
• Publication Date: 2015-07-08
• Subjects: Metals -- Physiological effect -- Periodicals; 572.51
• DOI: 10.1039/c4mt00345d
• Languages: English
• ISSNs: 1756-5901

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2687q2np" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />Competitive oxidative experiments with exogenous catechols show that copper–α-synuclein complexes can significantly promote endogenous peptide sulfoxidation at Met residues, which is relevant for protein oxidative damage.</p> </abstract>