Differential cytotoxicity of long-chain bases for human oral gingival epithelial keratinocytes, oral fibroblasts, and dendritic cells. Issue 1 (19th August 2015)

• Record Type: Journal Article
• Authors: Poulsen, Christopher; Mehalick, Leslie A.; Fischer, Carol L.; Lanzel, Emily A.; Bates, Amber M.; Walters, Katherine S.; Cavanaugh, Joseph E.; Guthmiller, Janet M.; Johnson, Georgia K.; Wertz, Philip W.; Brogden, Kim A.
• Is Part Of: Toxicology letters. Volume 237:Issue 1(2015)
• Page Start: 21
• Page End: 29
• Publication Date: 2015-08-19
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.05.012
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0040"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Long-chain bases sphingosine and dihydrosphingosine are in saliva and have antimicrobial activity against oral pathogens.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">We determined the toxicity of sphingosine, dihydrosphingosine, and phytosphingosine for GE keratinocytes, GF, DC, and SCC cells.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">The LD₅₀ of long-chain bases for GE keratinocytes, GF, SCC cells, and DC were considerably higher than their MIC for oral pathogens.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">This finding is important in pursuing the future potential of long-chain bases in treating periodontal and oral infections.</p> </list-item> </list> </p> </sec> </abstract>