Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression. Issue 1 (19th August 2015)

• Record Type: Journal Article
• Authors: Chiou, Yu-Hu; Liou, Saou-Hsing; Wong, Ruey-Hong; Chen, Chih-Yi; Lee, Huei
• Is Part Of: Toxicology letters. Volume 237:Issue 1(2015)
• Page Start: 46
• Page End: 54
• Publication Date: 2015-08-19
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.05.019
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0050"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Nickel accumulation in lung tissues is associated with EGFR mutations, miR-21 expression, and a poor outcome in lung cancer never-smoking patients.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Nickel-mediated miR-21 expression, at least in part, synergistically promotes invasiveness <italic>via</italic> decreased the expression of RECK and SPRY2 in EGFR-mutated lung cancer cells.</p> </list-item> </list> </p> </sec> </abstract>