The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate1. Issue 49 (21st June 2015)

• Record Type: Journal Article
• Authors: Sato, Kohei; Kitakaze, Keisuke; Nakamura, Takahiro; Naruse, Naoto; Aihara, Keisuke; Shigenaga, Akira; Inokuma, Tsubasa; Tsuji, Daisuke; Itoh, Kohji; Otaka, Akira
• Is Part Of: Chemical communications. Volume 51:Issue 49(2015)
• Page Start: 9946
• Page End: 9948
• Publication Date: 2015-06-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc02967h
• Languages: English
• ISSNs: 1359-7345

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj10144nsm" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />We describe a novel peptide ligation/desulfurization strategy using a β-mercapto-<italic>N</italic>-glycosylated asparagine derivative. The strategy is successfully applied to the total chemical synthesis of GM2 ganglioside activator protein.</p> </abstract>