Postinjury treatment with magnesium sulfate attenuates neuropathic pains following spinal cord injury in male rats. Issue 3 (April 2015)

• Record Type: Journal Article
• Authors: Farsi, Leila; Afshari, Khashayar; Keshavarz, Mansoor; NaghibZadeh, Maryam; Memari, Fereidoon; Norouzi-Javidan, Abbas
• Is Part Of: Behavioural pharmacology. Volume 26:Issue 3(2015)
• Publication Date: 2015-04
• Subjects: Psychopharmacology -- Periodicals; Nervous System -- drug effects -- Periodicals; Behavior -- drug effects -- Periodicals; 615.78
• DOI: 10.1097/FBP.0000000000000103
• Languages: English
• ISSNs: 0955-8810

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p>Spinal cord injury (SCI) has a number of severe and disabling consequences including chronic pain. Approximately 40% of patients experience neuropathic pain, which appears to be persistent. Previous studies have demonstrated the neuroprotective effects of magnesium sulfate (MgSO₄). We aimed to investigate the effect of MgSO₄ on neuropathic pains following SCI in male rats. Thirty-two adult male rats (weight 300–350 g) were used. After laminectomy, a complete SCI was induced by compression of the spinal cord for 1 min with an aneurysm clip. A single dose of 300 or 600 mg/kg MgSO₄ was injected intraperitoneally. Tail-flick latency and acetone drop test scores were evaluated before surgery and once a week for 4 weeks after surgery. Rats in groups SCI+Mg300 and SCI+Mg600 showed significantly higher mean tail-flick latencies and lower mean scores in the acetone test compared with those in the SCI+veh group 4 weeks after surgery (<italic>P</italic>&lt;0.05). These findings revealed that systemic single-dose administration of MgSO₄ can attenuate thermal hyperalgesia and cold allodynia induced by SCI in rats.</p> </sec> </abstract>