Glycosylated hemoglobin level and number of oral antidiabetic drugs predict whether or not glycemic target is achieved in insulin-requiring type 2 diabetes. Issue 2 (April 2015)

• Record Type: Journal Article
• Authors: Lin, Shi-Dou; Tsai, Shih-Tzer; Tu, Shih-Te; Su, Ching-Chieh; Chen, Jung-Fu; Lu, Chieh-Hsiang; Wang, Chao-Hung; Yu, Neng-Chun; Hsu, Shang-Ren; Hsieh, Ming-Chia
• Is Part Of: Primary care diabetes. Volume 9:Issue 2(2015)
• Page Start: 135
• Page End: 141
• Publication Date: 2015-04
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1016/j.pcd.2014.05.005
• Languages: English
• ISSNs: 1751-9918

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Aims</title> <p id="spar0005">Factors predicting success (glycosylated hemoglobin (A1C) < 7%) with insulin therapy in patients with insulin-requiring type 2 diabetes need to be identified.</p> </sec> <sec> <title id="sect0015">Methods</title> <p id="spar0010">A retrospective, multi-center, observational study was conducted for outpatients with oral antidiabetic drug (OAD)-treated type 2 diabetes whose A1C levels remained above 7%. Patients were begun on basal insulin between January 2005 and December 2006. Biochemical variables and demographic data were collected before and after 52 weeks of insulin therapy.</p> </sec> <sec> <title id="sect0020">Results</title> <p id="spar0015">A total of 565 patients (age, 60.4 ± 11.9 years; A1C levels, 10.11 ±1.81%; duration of diabetes, 11.5 ± 6.8 years) were studied. By study end, 63 patients (11.2%) had achieved the glycemic goal (A1C < 7%). The glycemic goal attainment rate was only 9.1% in patients with A1C > 8.8% and who were taking >2 OADs at baseline. The highest rate (32.7%) of successful glycemic control was observed in the group of patients with A1C ≤ 8.8% and who used ≤ 2 OADs at baseline.</p> </sec> <sec> <title id="sect0025">Conclusions</title> <p id="spar0020">Insulin-naïve diabetic patients with A1C > 8.8%, especially those who are taking >2 OADs, have small chance to achieve good glycemic control with adding only basal insulin therapy.</p> </sec> </abstract>