Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line. Issue 3 (April 2015)

• Record Type: Journal Article
• Authors: Lewinska, Anna; Siwak, Justyna; Rzeszutek, Iwona; Wnuk, Maciej
• Is Part Of: Toxicology in vitro. Volume 29:Issue 3(2015)
• Page Start: 417
• Page End: 425
• Publication Date: 2015-04
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2014.12.005
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st085">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0190">Flavonoids lowered cancer cell viability and proliferation in a different manner.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0195">Diosmin provoked apoptosis in DU145 cells.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0200">Flavonoids induced oxidative stress.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0205">Diosmin was found a potent inducer of DSBs and chromosomal damage.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0210">Diosmin-induced genotoxicity may result in cytotoxicity against cancer cells.</p> </list-item> </list> </p> </sec> </abstract>