Low concentrations of cylindrospermopsin induce increases of reactive oxygen species levels, metabolism and proliferation in human hepatoma cells (HepG2). Issue 3 (April 2015)

• Record Type: Journal Article
• Authors: Liebel, Samuel; de Oliveira Ribeiro, Ciro Alberto; de Magalhães, Valéria Freitas; da Silva, Rodrigo de Cássio; Rossi, Stéfani Cibele; Randi, Marco Antônio Ferreira; Filipak Neto, Francisco
• Is Part Of: Toxicology in vitro. Volume 29:Issue 3(2015)
• Page Start: 479
• Page End: 488
• Publication Date: 2015-04
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2014.12.022
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st095">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0215">Low concentrations of CYN (&lt;10 μg l⁻¹) produced limited toxicity in HepG2 cells.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0220">Pre-induction of CYPs slightly increased CYN toxicity.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0225">Low concentrations of CYN led to increases of HepG2 metabolism and proliferation.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0230">CYN-induced proliferation seems to depend on ROS signaling.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0235">Culture medium with 2% FBS may be appropriate for experiments with HepG2 cells.</p> </list-item> </list> </p> </sec> </abstract>