Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Issue 3 (April 2015)

• Record Type: Journal Article
• Authors: Van den Hof, Wim F.P.M.; Ruiz-Aracama, Ainhoa; Van Summeren, Anke; Jennen, Danyel G.J.; Gaj, Stan; Coonen, Maarten L.J.; Brauers, Karen; Wodzig, Will K.W.H.; van Delft, Joost H.M.; Kleinjans, Jos C.S.
• Is Part Of: Toxicology in vitro. Volume 29:Issue 3(2015)
• Page Start: 489
• Page End: 501
• Publication Date: 2015-04
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2014.12.016
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st145">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0270">Integrated analyses of transcriptome and metabonome results in relevant pathways.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0275">We could unravel mechanisms underlying Cyclosporin A-induced hepatotoxicity.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0280">The proposed model for drug-induced cholestasis provides valuable information.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0285">Cyclosporin A treatment impairs cholesterol metabolism and bile acid synthesis.</p> </list-item> </list> </p> </sec> </abstract>