The aryl hydrocarbon receptor-mediated and genotoxic effects of fractionated extract of standard reference diesel exhaust particle material in pulmonary, liver and prostate cells. Issue 3 (April 2015)

• Record Type: Journal Article
• Authors: Pálková, Lenka; Vondráček, Jan; Trilecová, Lenka; Ciganek, Miroslav; Pěnčíková, Kateřina; Neča, Jiří; Milcová, Alena; Topinka, Jan; Machala, Miroslav
• Is Part Of: Toxicology in vitro. Volume 29:Issue 3(2015)
• Page Start: 438
• Page End: 448
• Publication Date: 2015-04
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2014.12.002
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st105">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0165">Fractionated extract of standard DEP reference material was a potent AhR inducer.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0170">Both PAHs and polar aromatic compounds contributed to the AhR activation.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0175">Polar aromatic compounds contributed more significantly to DNA adduct formation.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0180">Cell-specific differences in activation of DNA damage response were identified.</p> </list-item> </list> </p> </sec> </abstract>