Predicting in vivo phospholipidosis-inducing potential of drugs by a combined high content screening and in silico modelling approach. Issue 3 (April 2015)

• Record Type: Journal Article
• Authors: Bauch, Caroline; Bevan, Samantha; Woodhouse, Heather; Dilworth, Clive; Walker, Paul
• Is Part Of: Toxicology in vitro. Volume 29:Issue 3(2015)
• Page Start: 621
• Page End: 630
• Publication Date: 2015-04
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.01.014
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st080">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0135">Two high content screening assays: phospholipidosis and lysosomal trapping.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0140">Validation of two cellular models: HepG2 and H9c2 cells.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0145">Applicability domains are required for compound classes like aminoglycosides.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0150"> <italic>In vitro</italic> and <italic>in silico</italic> methods to predict phospholipidosis <italic>in vivo</italic> are compared.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0155">Formulation of a screening strategy to better predict phospholipidosis <italic>in vivo</italic>.</p> </list-item> </list> </p> </sec> </abstract>