Indoxyl sulfate induces oxidative stress and hypertrophy in cardiomyocytes by inhibiting the AMPK/UCP2 signaling pathway. Issue 2 (16th April 2015)

• Record Type: Journal Article
• Authors: Yang, Ke; Xu, Xinli; Nie, Ling; Xiao, Tangli; Guan, Xu; He, Ting; Yu, Yanlin; Liu, Liang; Huang, Yunjian; Zhang, Jingbo; Zhao, Jinghong
• Is Part Of: Toxicology letters. Volume 234:Issue 2(2015)
• Page Start: 110
• Page End: 119
• Publication Date: 2015-04-16
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.01.021
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0050"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">IS induces ROS generation in cardiomyocytes by down-regulation of UCP2.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">UCP2 attenuates IS-induced cardiomyocyte hypertrophy by inhibiting ROS production.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">AMPK inactivation contributes to IS-induced UCP2 down-regulation.</p> </list-item> </list> </p> </sec> </abstract>