RNA degradation in antiviral immunity and autoimmunity. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Rigby, Rachel E.; Rehwinkel, Jan
• Is Part Of: Trends in immunology. Volume 36:Issue 3(2015)
• Page Start: 179
• Page End: 188
• Publication Date: 2015-03
• Subjects: Immunology -- Periodicals; 571.96
• DOI: 10.1016/j.it.2015.02.001
• Languages: English
• ISSNs: 1471-4906

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The nonsense-mediated decay (NMD) pathway defends cells against RNA virus invasion.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">NMD targets viral RNAs for degradation, including by the RNA exosome.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Genetic deficiencies in NMD and RNA exosome components cause autoimmunity.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">NMD and the RNA exosome prevent aberrant activation of innate immune responses.</p> </list-item> </list> </p> </sec> </abstract>