Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers. Issue 1 (April 2015)

• Record Type: Journal Article
• Authors: Kim, Moon-Young; Koh, Jaemoon; Kim, Sehui; Go, Heounjeong; Jeon, Yoon Kyung; Chung, Doo Hyun
• Is Part Of: Lung cancer. Volume 88:Issue 1(2015:Apr.)
• Page Start: 24
• Page End: 33
• Publication Date: 2015-04
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2015.01.016
• Languages: English
• ISSNs: 0169-5002

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We examine PD-L1, L2 expression and PD-1⁺, CD8⁺ cell in lung squamous cell carcinoma.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">PD-L1 and L2 are expressed in approximately one-fourth of patients.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">PD-L1 expression is significantly and consistently related with increased CD8⁺ cell.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">MET expression is correlated with PD-L2 expression and increased PD-1⁺ cells.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">This provides rationale for anti-PD-1/PD-L1 immunotherapy in squamous cell carcinoma.</p> </list-item> </list> </p> </sec> </abstract>