Chronic nicotine exposure mediates resistance to EGFR-TKI in EGFR-mutated lung cancer via an EGFR signal. Issue 1 (April 2015)

• Record Type: Journal Article
• Authors: Togashi, Yosuke; Hayashi, Hidetoshi; Okamoto, Kunio; Fumita, Soichi; Terashima, Masato; de Velasco, Marco A.; Sakai, Kazuko; Fujita, Yoshihiko; Tomida, Shuta; Nakagawa, Kazuhiko; Nishio, Kazuto
• Is Part Of: Lung cancer. Volume 88:Issue 1(2015:Apr.)
• Page Start: 16
• Page End: 23
• Publication Date: 2015-04
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2015.01.027
• Languages: English
• ISSNs: 0169-5002

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Chronic nicotine exposure mediates resistance to EGFR-TKI in <italic>EGFR</italic>-mutated NSCLC.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The resistance arises from the EGFR signal activation through nAChR.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">A smoking history is associated with a shorter PFS on EGFR-TKI treatment.</p> </list-item> </list> </p> </sec> </abstract>