Nicotine induces resistance to erlotinib via cross-talk between α 1 nAChR and EGFR in the non-small cell lung cancer xenograft model. Issue 1 (April 2015)

• Record Type: Journal Article
• Authors: Li, Heyan; Wang, Shuo; Takayama, Koichi; Harada, Taishi; Okamoto, Isamu; Iwama, Eiji; Fujii, Akiko; Ota, Keiichi; Hidaka, Noriko; Kawano, Yuko; Nakanishi, Yoichi
• Is Part Of: Lung cancer. Volume 88:Issue 1(2015:Apr.)
• Page Start: 1
• Page End: 8
• Publication Date: 2015-04
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2015.01.017
• Languages: English
• ISSNs: 0169-5002

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Nicotine affects EGFR/AKT/ERK pathways in NSCLCs.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Nicotine promotes tumor growth and induces erlotinib-resistance in the PC9 model.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Chronic nicotine exposure causes more significant erlotinib-resistance <italic>in vivo</italic>.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Cross-talk between α 1 nAChR and EGFR is associated with EGFR-TKI resistance.</p> </list-item> </list> </p> </sec> </abstract>