The effects of the CXCR2 antagonist, MK-7123, on bone marrow functions in healthy subjects. Issue 2 (April 2015)

• Record Type: Journal Article
• Authors: Hastrup, Nina; Khalilieh, Sauzanne; Dale, David C.; Hanson, Lars G.; Magnusson, Peter; Tzontcheva, Anjela; Tseng, Jack; Huyck, Susan; Rosenberg, Elizabeth; Krogsgaard, Kim
• Is Part Of: Cytokine. Volume 72:Issue 2(2015)
• Page Start: 197
• Page End: 203
• Publication Date: 2015-04
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.01.002
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st125">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0185">CXCR2 antagonists such as MK-7123 may be useful anti-inflammatory agents.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0190">MK-7123 results in a reversible decline in absolute neutrophil counts (ANC).</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0195">The mechanism of neutrophil decline is unknown.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0200">The effect of MK-7123 on myelopoiesis was evaluated as a mechanism of ANC decline.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0205">The decrease in ANC was without measurable myelosuppressive effects.</p> </list-item> </list> </p> </sec> </abstract>