Unravelling adverse reactions to NSAIDs using systems biology. (March 2015)

• Record Type: Journal Article
• Authors: Perkins, James R.; Sanak, Marek; Canto, Gabriela; Blanca, Miguel; Cornejo-García, José Antonio
• Is Part Of: Trends in pharmacological sciences. Volume 36:Number 3(2015)
• Page Start: 172
• Page End: 180
• Publication Date: 2015-03
• Subjects: Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2014.12.003
• Languages: English
• ISSNs: 0165-6147

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The underlying mechanisms of adverse drug reactions (ADRs) are not fully understood.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Systems biology may help piece together genetic, transcriptomic, and epigenetic data.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Such methods can help find novel genes for further study and prioritise putative SNPs.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Examples include the use of gene networks and searches for SNPs that affect expression.</p> </list-item> </list> </p> </sec> </abstract>