Direct Correlation Between Double K-RAS Mutation and Mucinous Carcinoma. A Case Report. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Pacini, Luca; Bastianelli, Daniela; Ponti, Donatella; Rosa, Paolo; Petrozza, Vincenzo; Giannini, Giuseppe; Ragona, Giuseppe; Calogero, Antonella
• Is Part Of: Applied immunohistochemistry & molecular morphology. Volume 23:Issue 2(2015)
• Publication Date: 2015-02
• Subjects: Diagnostic immunohistochemistry -- Periodicals; Immunohistochemistry -- Periodicals; Cells -- Morphology -- Periodicals; Molecular diagnosis -- Periodicals; 616.079
• DOI: 10.1097/PAI.0000000000000176
• Languages: English
• ISSNs: 1541-2016

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p>Mutations at the <italic>K-RAS</italic> locus in colon cancer cells are frequently associated with lack of responsiveness to therapy with EGFR inhibitors, as a consequence of the activation of Ras-dependent intracellular signals. Here we report a colon cancer case carrying a novel combination of K-RAS mutations involving codon 13 (Gly to Asp) and codon 19 (Leu to Phe), on separate alleles. The double mutation was restricted to tumor cells bearing a mucinous-like phenotype.</p> </sec> </abstract>