Secretory proteins without a transport signal are retained in secretory granules during maturation in rat parotid acinar cells. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Katsumata-Kato, Osamu; Yokoyama, Megumi; Matsuki-Fukushima, Miwako; Narita, Takanori; Sugiya, Hiroshi; Fujita-Yoshigaki, Junko
• Is Part Of: Archives of oral biology. Volume 60:Issue 4(2015:Apr.)
• Page Start: 642
• Page End: 649
• Publication Date: 2015-04
• Subjects: Mouth -- Periodicals; Mouth -- Diseases -- Periodicals; Dentistry -- Periodicals; Electronic journals; 617.6005
• DOI: 10.1016/j.archoralbio.2015.01.006
• Languages: English
• ISSNs: 0003-9969

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The acinar cells of parotid glands from isoproterenol-treated rats were isolated.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The tracer uptake in immature secretory granules and during secretion was assessed.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">The intracellular localization of the tracer was confirmed by electron microscopy.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">The results show that the tracer was retained in the granules after maturation.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">We conclude that secretory proteins do not require a signal for their retention.</p> </list-item> </list> </p> </sec> </abstract>