Modulation of the CD4+ T cell response after acellular pertussis vaccination in the presence of TLR4 ligation. Issue 12 (17th March 2015)

• Record Type: Journal Article
• Authors: Brummelman, Jolanda; Helm, Kina; Hamstra, Hendrik-Jan; van der Ley, Peter; Boog, Claire J.P.; Han, Wanda G.H.; van Els, Cécile A.C.M.
• Is Part Of: Vaccine. Volume 33:Issue 12(2015)
• Page Start: 1483
• Page End: 1491
• Publication Date: 2015-03-17
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.01.063
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The duration of protection by current acellular pertussis vaccines is disappointing.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">TLR4 ligand improve acellular pertussis vaccine-induced T cell response in mice.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Adding TLR4 ligand to the vaccine induces pertussis-specific Th1/Th17 cells.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Frequency central memory pertussis-specific T cells are increased by TLR4 ligation.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">TLR4-based adjuvant could be a feasible solution to improve the current vaccine.</p> </list-item> </list> </p> </sec> </abstract>