Design, synthesis and evaluation of a gonadotropin releasing hormone-based subunit vaccine in rams (Ovis aries). Issue 12 (17th March 2015)

• Record Type: Journal Article
• Authors: Goodwin, Daryn; Varamini, Pegah; Simerska, Pavla; D'Occhio, Michael J.; Toth, Istvan
• Is Part Of: Vaccine. Volume 33:Issue 12(2015)
• Page Start: 1453
• Page End: 1458
• Publication Date: 2015-03-17
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.01.076
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Synthesis of a gonadotropin-releasing hormone-based (GnRH) lipopeptide vaccine.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The first use of a unique T helper epitope in rams.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Immunising rams with the lipopeptide with/without additional adjuvant AdjuVac™.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Significant anti-GnRH antibodies in both groups after intramuscular injection.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0920">A major advance in the development of lipopeptide-based subunit vaccines.</p> </list-item> </list> </p> </sec> </abstract>