Eradication of respiratory tract MRSA at a large adult cystic fibrosis centre. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Hall, H.; Gadhok, R.; Alshafi, K.; Bilton, D.; Simmonds, N.J.
• Is Part Of: Respiratory medicine. Volume 109:Issue 3(2015)
• Page Start: 357
• Page End: 363
• Publication Date: 2015-03
• Subjects: Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2015.01.013
• Languages: English
• ISSNs: 0954-6111

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Summary</title> <sec> <title id="sectitle0015">Introduction</title> <p id="abspara0010">The prevalence of MRSA in patients with CF is increasing. There is no consensus as to the optimum treatment.</p> </sec> <sec> <title id="sectitle0020">Method</title> <p id="abspara0015">An observational cohort study of all patients with MRSA positive sputum, 2007–2012. All eradication attempts with subsequent culture results were reviewed. Single vs dual antibiotic regimens were compared for both new and chronic infections.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">37 patients (median FEV₁ 58.7 (27.6–111.5)% predicted) were identified, of which 67.6% (<italic>n</italic> = 25) had newly acquired MRSA. Compared with single regimens, a high proportion of dual regimens achieved MRSA eradication (84.6% vs 50%; <italic>p</italic> = 0.1) for new infections. Rifampicin/Fusidic acid was associated with high success rates (100% vs 60% for other dual regimens (<italic>p</italic> = 0.13)). Compared with new infections, chronic MRSA was much less likely to be eradicated (18.2%, <italic>p</italic> = 0.01).</p> </sec> <sec> <title id="sectitle0030">Conclusion</title> <p id="abspara0025">Combined antibiotic therapy, particularly Rifampicin/Fusidic acid, is a well-tolerated and effective means of eradicating MRSA in patients with cystic fibrosis.</p> </sec> </abstract>