Molecular typing of antibiotic-resistant Staphylococcus aureus in Nigeria. Issue 2 (March 2015)

• Record Type: Journal Article
• Authors: O'Malley, S.M.; Emele, F.E.; Nwaokorie, F.O.; Idika, N.; Umeizudike, A.K.; Emeka-Nwabunnia, I.; Hanson, B.M.; Nair, R.; Wardyn, S.E.; Smith, T.C.
• Is Part Of: Journal of infection and public health. Volume 8:Issue 2(2015)
• Page Start: 187
• Page End: 193
• Publication Date: 2015-03
• Subjects: Communicable diseases -- Periodicals; Public health -- Periodicals; Epidemiology -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Medical microbiology -- Periodicals; 614.4
• DOI: 10.1016/j.jiph.2014.08.001
• Languages: English
• ISSNs: 1876-0341

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Summary</title> <sec> <title id="sect0010">Background</title> <p id="spar0005">Antibiotic-resistant <italic>Staphylococcus aureus</italic> including methicillin-resistant strains (MRSA) are a major concern in densely populated urban areas. Initial studies of <italic>S. aureus</italic> in Nigeria indicated existence of antibiotic-resistant <italic>S. aureus</italic> strains in clinical and community settings.</p> </sec> <sec> <title id="sect0015">Methods</title> <p id="spar0010">73 biological samples (40 throat, 23 nasal, 10 wound) were collected from patients and healthcare workers in three populations in Nigeria: Lagos University Teaching Hospital, Nigerian Institute of Medical Research, and Owerri General Hospital.</p> </sec> <sec> <title id="sect0020">Results</title> <p id="spar0015"> <italic>S. aureus</italic> was isolated from 38 of 73 samples (52%). Of the 38 <italic>S. aureus</italic> samples, 9 (24%) carried the Panton-Valentine leukocidin gene (PVL) while 16 (42%) possessed methicillin resistance genes (<italic>mec</italic>A). Antibiotic susceptibility profiles indicated resistance to several broad-spectrum antibiotics.</p> </sec> <sec> <title id="sect0025">Conclusion</title> <p id="spar0020">Antibiotic-resistant <italic>S. aureus</italic> isolates were recovered from clinical and community settings in Nigeria. Insight about <italic>S. aureus</italic> in Nigeria may be used to improve antibiotic prescription methods and minimize the spread of antibiotic-resistant organisms in highly populated urban communities similar to Lagos, Nigeria.</p> </sec> </abstract>