Mx GTPases: dynamin-like antiviral machines of innate immunity. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Haller, Otto; Staeheli, Peter; Schwemmle, Martin; Kochs, Georg
• Is Part Of: Trends in microbiology. Volume 23:Issue 3(2015)
• Page Start: 154
• Page End: 163
• Publication Date: 2015-03
• Subjects: Microbiology -- Periodicals; Infection -- Periodicals; Virulence (Microbiology) -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Virulence -- Periodicals; Microbiologie -- Périodiques; Infection -- Périodiques; Virulence (Microbiologie) -- Périodiques; Infection; Microbiology; Virulence (Microbiology); 579
• DOI: 10.1016/j.tim.2014.12.003
• Languages: English
• ISSNs: 0966-842X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Mx proteins are key intracellular restriction factors with broad antiviral activity.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Mx proteins have the typical three-domain architecture of dynamin-like GTPases.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Highly variable Mx domains serve as antiviral interfaces under evolutionary pressure.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Human MxB (MX2) is a newly identified interferon-induced restriction factor for HIV-1.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">A few amino acids of the viral nucleocapsid proteins NP and CA determine MxA (MX1) sensitivity of influenza A viruses and MxB (MX2) sensitivity of HIV-1, respectively.</p> </list-item> </list> </p> </sec> </abstract>