Prothrombin complex concentrate is associated with death and thomboembolic complications in patients with severe coagulopathy or active bleeding. Issue 1 (February 2015) - Shute, W.; Chan, M.; Nandal, S.; Lluch-Candal, C.; Knott, C.; Glassford, N.; Arumugaswamy, A.; Smith, C.; Mårtensson, J.; Bellomo, R.