Functional genomics of PCOS: from GWAS to molecular mechanisms. (March 2015)

• Record Type: Journal Article
• Authors: McAllister, Jan M.; Legro, Richard S.; Modi, Bhavi P.; Strauss, Jerome F.
• Is Part Of: Trends in endocrinology and metabolism. Volume 26:Number 3(2015)
• Page Start: 118
• Page End: 124
• Publication Date: 2015-03
• Subjects: Endocrinology -- Periodicals; Metabolism -- Periodicals; Metabolism; 616.4
• DOI: 10.1016/j.tem.2014.12.004
• Languages: English
• ISSNs: 1043-2760

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">GWAS have identified <italic>FHSR, LHCGR, INSR</italic>, and <italic>DENND1A</italic> as PCOS candidate genes.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Overexpression of DENND1A variant 2 increases androgen biosynthesis in theca cells from normal cycling women, converting them to a PCOS phenotype.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015"> <italic>DENND1A, LHCGR, INSR</italic>, and <italic>RAB5B</italic> form a hierarchal signaling network that can influence androgen synthesis.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">DENND1A variant 2 is a new diagnostic and therapeutic target for PCOS.</p> </list-item> </list> </p> </sec> </abstract>