Limited miR-17-92 overexpression drives hematologic malignancies. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Danielson, Laura S.; Reavie, Linsey; Coussens, Marc; Davalos, Veronica; Castillo-Martin, Mireia; Guijarro, Maria V.; Coffre, Maryaline; Cordon-Cardo, Carlos; Aifantis, Iannis; Ibrahim, Sherif; Liu, Cynthia; Koralov, Sergei B.; Hernando, Eva
• Is Part Of: Leukemia research. Volume 39:Issue 3(2015:Mar.)
• Page Start: 335
• Page End: 341
• Publication Date: 2015-03
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2014.12.002
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Developed model with limited miR-17-92 overexpression across hematopoietic lineages.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">miR-17-92 expression is sufficient to <italic>drive</italic> B cell malignancies.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">SM22α-cre mediated recombination occurs in virtually all hematopoietic lineages.</p> </list-item> </list> </p> </sec> </abstract>