Drug transporters play a key role in the complex process of Imatinib resistance in vitro. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Alves, Raquel; Fonseca, Ana Raquel; Gonçalves, Ana C.; Ferreira-Teixeira, Margarida; Lima, Joana; Abrantes, Ana M.; Alves, Vera; Rodrigues-Santos, Paulo; Jorge, Lénia; Matoso, Eunice; Carreira, Isabel M.; Botelho, Maria Filomena; Sarmento-Ribeiro, Ana B.
• Is Part Of: Leukemia research. Volume 39:Issue 3(2015:Mar.)
• Page Start: 355
• Page End: 360
• Publication Date: 2015-03
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2014.12.008
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We establish the first Imatinib resistant cell line by discontinuous exposure.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">This model elucidated the importance of treatment interruptions in resistance.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">In both resistant models, efflux transporters were increased comparing to K562.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Influx transporters expression were diminished in both resistant cell lines.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Our results show the importance of ABC transporters as therapeutic targets.</p> </list-item> </list> </p> </sec> </abstract>